The source of this article is: https://jbhandleyblog.com/home/2018/4/1/international2018
The formatting there will be better than my copy here.
What I add to the conversation is the Globalist Angle.
I have little doubt that these scientists are correct in their research and associations, but they are biologists, not political scientists.
Were we to put the two fields of expertise together we would find that the ruling elite is better served by autistic serfs and families burdened by supporting autistic family members than by whole, strong and independent un-poisoned individuals.
This is Aldous Huxley’s Brave New World playing out 85 years after it was published.
Mainstream overlooking the causes of autism is not accidental.
I encourage you to shift your thinking from “How could they be so stupid” to what more logically explains ignoring the facts, “How could we elect such evil people” … and re-elect them for decades.
I now turn the conversation over to the scientists.
Read it here or at the source:
https://jbhandleyblog.com/home/2018/4/1/international2018
What will Americans do?BY J.B. HANDLEY April 2, 2018 Five clear, replicable, and related discoveries explaining how autism is triggered have formed an undeniably clear picture of autism’s causation, and possibly ways to alleviate the symptoms, too. Most of the research that has created this understanding has been published in the last 36 months, and largely from international scientists in the United Kingdom, Canada, France, Israel, and China. The American media, public health authorities, and Autism Speaks? Silent. STAFFORDSHIRE, England?—In early December 2017, Dr. Chris Exley of Keele University in England and his colleagues published a paper that for the first time looked at the brain tissue of subjects with autism to determine the level of aluminum (note: they spell “aluminum” as “aluminium” in the United Kingdom) found within their brain tissue. For anyone trying to convince the world that “the science is settled and vaccines don’t cause autism,” the study’s findings are deeply contradictory to that statement. In a blog post written by Professor Exley on the day his study was published, he explained the groundbreaking results:
 Dr. Chris Exley of Keele University Dr. Exley’s quote includes a reference to “monocytes at injection sites” and the fact that the interaction between these monocytes and aluminum has been demonstrated in previous published science. I know, that sounds pretty technical, but bear with me. A “monocyte” is a type of white blood cell, of which one form of monocyte is a “macrophage.” A macrophage can be thought of as the garbage man of the immune system, eating up foreign substances, cell debris, etc. As you will see in a moment, macrophages appear to be playing a critical and devastating role in triggering autism, serving to escort aluminum injected from a vaccine directly into the brain, where it can disrupt brain development and trigger autism. Dr. Exley’s study?—?“Aluminium in brain tissue and autism”?—?is the final piece of a puzzle that first started to come together in 2004, and picked up steam since 2010, that has dramatically furthered the scientific understanding of exactly how a vaccine can trigger autism. This timeline is critical to recognize, because the Vaccine Court in the United States dismissed the vaccine-autism hypothesis in 2009, long before most of what I’m about to explain even existed. Science is a continuum, an emergence of truth through many different studies that often have to be pieced together before the picture becomes clear. And, scientific progress can sometimes move slowly until that moment when an emerging truth presents itself in such a way that it can no longer be denied. In my opinion, Dr. Exley’s study provided the only data missing from an airtight explanation of what happened to my son and so many other children.
Why is aluminum in vaccines at all? Aluminum is a critical component of most vaccines given to children. It serves as an “adjuvant” meaning the aluminum serves to “wake up” the immune system, provoking the immune system to recognize the “antigen” within the vaccine for whatever disease the vaccine serves to protect against. The amount of aluminum in vaccines given to children skyrocketed beginning in the early 1990s for two reasons: 1), more vaccines were added to the children’s vaccine schedule and, 2), the vaccination rate for all vaccines given to children rose (from 50–60% of children vaccinated in the mid-1980s to over 90% today). A child in the mid-1980s would have received 1,250 micrograms of aluminum from their vaccines by their 18-month birthday if they were fully vaccinated. Today, that number is 4,925 micrograms, a near-quadrupling of total aluminum. You can read more about this in an excellent study published by Neil Miller, here’s an image from the study:  Mystifyingly, aluminum has never experienced biological testing to consider its safety for being injected into babies, having been “grandfathered” into our modern safety standards. Canadian scientists Dr. Chris Shaw and Dr. Lucija Tomljenovic addressed this omission in a critical study they published in 2011 in Current Medicinal Chemistry titled, “Aluminum Vaccine Adjuvants: Are they Safe?” They wrote:
I wrote an extensive article in January about the way aluminum’s safety has been mismanaged, you can read that article right here: Ground zero at CaltechWhen Caltech scientist Dr. Paul Patterson passed away in 2014, I had little appreciation that he had triggered a chain of events over the course of his career that may now provide a clear and unambiguous explanation of how and why my son developed autism back in 2004. Knowing exactly how my son’s autism was caused is incredibly important to my wife and I, because the more information we have about causation, the more chance we have to do something about it, and perhaps recover my son from an affliction now impacting 1 in 36 American kids. What you’re about to read is the product of more than two dozen very recent peer-reviewed published scientific studies, with really no original thought by me. I’m a businessman and a father, but what follows is a “grand theory of autism” so complete and well-supported that I think it deserves the attention of every member of the autism community. When the totality of this explanation became clear to me, not only did my jaw hit the floor, but I was immediately consumed with thoughts about how this clear explanation might impact the way we treat our son’s autism, and I hope it does the same for you and perhaps your doctor as well. What I’m certain of is that this “grand theory” needs to be heavily debated, and I hope by putting it in the public realm I help move it along that path. (I’m indebted to an anonymous scientist who runs a website called Vaccine Papers, where many of these insights came from. I will quote VP throughout this piece, referring to VP as “VP.” I highly recommend you read the totality of his website, where the explanations are far more scientific than what you will read here.) It shouldn’t be a surprise that all of this science has been published outside the United States. I’ve listened closely to the stories of American scientists wanting to study autism and complaining that any studies that are even remotely controversial are nearly impossible to fund or get approved. Discovery #1: “Maternal Immune Activation” can cause autismWhile Dr. Patterson’s passing wasn’t something I was aware of at the time, it was certainly recognized by the scientific community, of which his obituary from Caltech explains in great detail.  Dr. Patterson’s “research focused on interactions between the nervous and immune systems?—?a connection that was not universally acknowledged in the early days of neuroscience”explains his obituary, “he became intrigued by epidemiological studies that had linked a severe viral or bacterial infection during pregnancy with the increased risk of a woman giving birth to a child with a neurodevelopmental disorder such as schizophrenia or autism. Patterson and his coworkers reproduced this human effect in mice using a viral mimic that triggers an infection-like immune response in the mother, producing in the offspring the core behavioral symptoms associated with autism and schizophrenia.” In 2006, Dr. Patterson introduced his complex understanding of the interaction between the immune system and neurodevelopment through an excellent article in the Engineering & Science journal, titled Pregnancy, Immunity, Schizophrenia, and Autism. I hope you’ll take the time to read this for yourself, Dr. Patterson does a great job of explaining his discovery to the uninitiated, it’s really a seminal work. Here’s a quote:
Are you with me so far? Basically, what Dr. Patterson is saying is that if a pregnant mother gets sick (virus, bacteria) while pregnant?—?an event that “activates” her immune system?—?that activation can impact the neurodevelopment (how exactly the brain is constructed) of her fetus, potentially leading to neurological problems after birth. Dr. Patterson took this explanation a step further, explaining that the brains of people with autism reflect the immune system activation that took place, even decades later, as he cites valuable work being done at Johns Hopkins:
While Dr. Pardo and colleagues were the first to find this “microglial activation” in the brain of children with autism, this finding has now been replicated many times, here’s a study from Japan in 2013 finding the same thing: “In conclusion, the present PET measurements revealed marked activation of microglia in multiple brain regions of young adults with ASD. The results strongly support the contention that immune abnormalities contribute to the etiology of ASD.” If you’re going to take one thing away from this section, I’d recommend an excerpt from Dr. Patterson’s quote worth memorizing:
Is that what happened (and still is happening) to my son? Further Refinement of Discovery #1: Immune Activation from the Cytokine Interleukin-6If you’re an autism parent, you’ve probably heard the expression “cytokine storm” and half-understood what that might mean (anything with “storm” at the end of it can’t be good?—?what this really means is a chronic, slow burn inflammation in the brain). In 2006, Dr. Patterson and his colleagues were speculating that the immune system’s cytokines might be responsible for altering the brain development of the fetus during gestation: “Cytokines are produced by the white blood cells, and their levels in the blood increase when we get an infection…We think that maternal immune activation alters brain circuits…there’s that permanent, subclinical, altered immune state in the autistic brain?—?those increased cytokine levels…are they [cytokines] actually interacting with the brain in an ongoing fashion, with consequences visible in the patients’ behavior? I favor [the cytokine] hypothesis.” Study Link HERE Just a year after Dr. Patterson’s excellent article about Maternal Immune Activation (“MIA”), he and his colleagues produced the first study that took their understanding of cytokines to a more detailed level. Knowing that MIA was producing offspring with neurological disorders (in their mouse model), they wanted to find out what?—?exactly WHAT?—?was causing the altered brain development. They figured it was a cytokine (of which there are many), but which one? As the Patterson and his colleagues noted, “however, the mechanism by which MIA causes long-term behavioral deficits in the offspring is unknown.” That is until they discovered it:
In the case of the 2007 experiment, Patterson and his colleagues injected pregnant mice with a specific cytokine?—?interleukin-6 (“IL-6”)?—?and saw changes in the neurology of their offspring. Replication of Dr. Patterson’s discovery about MIA and IL-6Dr. Patterson’s work was groundbreaking. He tied the immune system and brain together in ways previously not recognized. Like all great new discoveries in science, Dr. Patterson’s theories have since been replicated many times. In 2012, Dr. Patterson and his colleagues produced this paper,which was more autism-specific and reached a similar conclusion: “These results indicate that MIA yields male offspring with deficient social and communicative behavior, as well as high levels of repetitive behaviors, all of which are hallmarks of autism.” Study link HERE In 2014, the M.I.N.D. Institute at UC-Davis published an important study that took Dr. Patterson’s work in mice and replicated it in monkeys. Why do monkeys matter? The study authors explained: “Maternal infection during pregnancy is associated with an increased risk of schizophrenia and autism in the offspring. Supporting this correlation, experimentally activating the maternal immune system during pregnancy in rodents produces offspring with abnormal brain and behavioral development. We have developed a nonhuman primate model to bridge the gap between clinical populations and rodent models of maternal immune activation (MIA).” And, the M.I.N.D. Institute scientists saw similar results to what had been found in mice: “In this rhesus monkey model, MIA yields offspring with abnormal repetitive behaviors, communication, and social interactions. These results extended the findings in rodent MIA models to more human-like behaviors resembling those in both autism and schizophrenia.” There are many additional studies that support Dr. Patterson’s findings, here’s one more to make the point from Neuroscience?—?Brain IL-6 elevation causes neuronal circuitry imbalances and mediates autism-like behaviors?—?published in 2012: “In summary, our study supports a critical role of IL-6 elevation in modulating autism-like behaviors through impairments on synapse formation, dendritic spine development, as well as on neuronal circuit balance. These findings suggest that manipulation of IL-6 may be a promising avenue for therapeutic interventions.” Dr. Patterson: what can cause immune activation?Dr. Patterson helped establish as scientific fact that an MIA during pregnancy can cause autism. As a parent, I’m haunted by Dr. Patterson’s words that “there’s an ongoing, permanent immune-system activation in the brains of autistic people.” If that’s really what’s happening to my son, it creates an obvious question: What can we do about it? It’s why understanding exactly what happened to my son is so important… 
…And why there’s something else Dr. Patterson mentioned in his 2006 magazine article, something that today might get him run out of Caltech but was still allowed in the scientific discourse back then, he said this:
Dr. Patterson said it, so I don’t have to be the first to bring it up. He said a vaccination “activates the immune system” and he also told us that “immune activation” can cause autism. How exactly does a vaccine activate the immune system? Answer: Aluminum hydroxide, aka “aluminum adjuvant”.Discovery #2: Aluminum Adjuvant causes immune activation and is far more neurotoxic than previously thoughtAluminum compounds (Al hydroxide and Al phospate) are the most common adjuvants used in vaccines. They are currently used in the hepatitis A, hepatitis B, diphtheria-tetanus-pertussis(DTaP, Tdap), Haemophilus influenzae type b (Hib), human papillomavirus (HPV) and pneumococcus (PCV) vaccines. Aluminum adjuvant “activates” the immune system, which induces long term immunity to antigens in the vaccine. The scientific understanding of aluminum adjuvant toxicity has changed and deepened dramatically in recent years (since 2007).In fact, the published research on aluminum adjuvant is so new it has not even been considered by our FDA or CDC, who are still basing their recommendations about aluminum use in vaccines on a study published in 2011 that erroneously concluded that aluminum from a vaccine likely ends up in the body’s skeletal system: “While the contribution of vaccines to an infant’s aluminum body burden can be slightly higher than that of the dietary contribution in our model, the fact that the primary pool where the aluminum is residing, as a long-term storage depot, is likely to be skeletal and not a more sensitive soft organ system is reassuring.” Most of the guess work about aluminum is based on dissolved aluminum, not aluminum hydroxide, which is the type of aluminum used in vaccines. We’re now learning that aluminum hydroxide is a nanoparticle, absorbed by our body’s macrophage (the immune system’s garbage man) where the macrophage can then easily transport the aluminum hydroxide to the brain (the macrophage passes easily through the blood-brain barrier). If you’d like to see a complete takedown of the “safe level” of aluminum argument still made by the FDA and CDC, see VP’s excellent work, here’s a short excerpt: “It is not reasonable or scientific to use studies of ingested, water-soluble aluminum salts (like AlCl3 or Al-lactate) to establish a safe dose of injected aluminum adjuvant (comprising aluminum hydroxide/phosphate nanoparticles). The chemical forms and route of administration are different. It is well-established today that nanoparticles can have higher toxicity than bulk orsoluble forms of the same material…It’s the vaccine promoters that created this inherently-invalid approach to aluminum adjuvant safety. Vaccine critics including me argue that the safety of injected aluminum adjuvant can only be tested using injected aluminum adjuvant, not ingested aluminum salts like AlCl3 or Al lactate. This should be common sense. So, leaving aside the important issues of nanoparticle toxicity and administration route, I want to address the question: is it really true that animals (mice or rats) are not harmed by ingesting 62mg/kg/day or 26 mg/kg/day aluminum? After all, this is the fundamental basis for aluminum adjuvant safety. Vaccine promoters rely on Keith and Mitkus to make the case that aluminum adjuvant is safe, and Keith and Mitkus depend on the claim that these dosages are safe for animals to ingest. If the 26 mg/kg/day dosage is in fact harmful to animals, then the analyses by Keith and Mitkus are wrong and unsalvageable. Several studies clearly demonstrate that dosages much lower than 26 mg/kg/day are harmful, and they are presented below.” The first time I personally woke up to the the idea that the aluminum adjuvant used in vaccines might be far more toxic and dangerous than I knew was when I started reading about the incredible work of Dr. Chris Shaw at the University of British Columbia in Canada. (Check out this video of Dr. Shaw discussing aluminum adjuvant, and some of the experiments he and his colleagues did on mice.) In 2007, Dr. Shaw published the first study looking at injected aluminum adjuvant in this paper, Aluminum Adjuvant Linked to Gulf War Illness Induces Motor Neuron Death in Mice and sounded a worldwide alarm about the dangers of aluminum adjuvant:
In 2009, Dr. Shaw’s and his colleagues in British Columbia published another study looking at injected aluminum hydroxide, and the results were deeply disturbing:
2012: Mechanisms of aluminum adjuvant toxicity and autoimmunity in pediatric populations Three years after his groundbreaking study, Dr. Shaw and his colleague, Dr. Lucija Tomljenovic, published this paper in 2012, expressing grave concerns about the limited understanding of aluminum adjuvant’s toxicity:
The two scientists called for an urgent reevaluation of the safety profile of aluminum adjuvant-containing vaccines:
2013: Slow CCL2-dependent translocation of biopersistent particles from muscle to brain In 2013, French scientists demonstrated that aluminum adjuvant, when injected into the body of a mouse, ended up in the brain 1 year later. The study authors expressed serious concerns about this very new discovery: “However, continuously escalating doses of this poorly biodegradable adjuvant in the population may become insidiously unsafe, especially in the case of overimmunization or immature/altered blood brain barrier…” The authors chose their words carefully, recognizing the ubiquity of aluminum adjuvant’s use in pediatric vaccines all over the world, which is why their choice to call aluminum adjuvant “insidiously unsafe” should cause any parent worry. Unfortunately, the very thing they express real concern about?—?escalating doses?—?is exactly what has been happening to children since the early 1990s, when the immunization schedule in the U.S. and all over the world more than tripled, largely due to new vaccines being introduced that contain aluminum adjuvant. 2015: Biopersistence and brain translocation of aluminum adjuvants of vaccines In 2015, another study from Université Paris Est Créteil (UPEC) in France further supported this new view of aluminum adjuvant as a dangerous, biopersistent, and ultimately brain-injuring toxin. (The study confirmed that aluminum adjuvant slowly makes its way to the brain, where it then stays, possibly forever.) Read study HERE The study explained that aluminum adjuvant can generate a long-term immune response because of its “biopersistence”, which basically means our body has no ability to rid itself of aluminum adjuvant, because its a man-made substance we have no natural designs to eliminate: “Thus alum and other poorly biodegradable materials taken up at the periphery by phagocytes circulate in the lymphatic and blood circulation and can enter the brain using a Trojan horse mechanism similar to that used by infectious particles. Previous experiments have shown that alum administration can cause CNS dysfunction and damage, casting doubts on the exact level of alum safety.” November 2016: Non-linear dose-response of aluminium hydroxide adjuvant particles: Selective low dose neurotoxicity And, just last Fall in 2016, the most important and revealing study yet done on aluminum adjuvant provided more bad news, and more insight. It’s safe to say that this study’s conclusions have revolutionized our understanding of aluminum adjuvant. From the journal Toxicology, the French study authors were very concerned about the widespread use of aluminum adjuvant:
They also discovered, through mouse-models, a deeply alarming unique characteristic of aluminum adjuvant: low, consistent doses were MORE neurotoxic than a single bolus dose:
Read study HERE This a counter-intuitive conclusion, but profoundly important, so I’m bringing in VP to further explain:
The study authors also disputed the way the FDA and CDC currently think about aluminum adjuvant toxicity, basically saying that the current approach is wrong:
And, the French scientists finish with a conclusion that all parents should find very troubling: “In the context of massive development of vaccine-based strategies worldwide, the present study may suggest that aluminium adjuvant toxicokinetics and safety require reevaluation.”Reminder: this study has only been public for just over a year. Please watch this incredibly thoughtful and detailed interview Dr. Romain Gerard, the study’s lead author. It’s in French with English subtitles: Discovery #3: Aluminum can increase IL-6 in the brainOne of the only frustrations of the remarkable toxicity studies on aluminum adjuvant coming out of France is that many scientists did not explicitly measure the mice brains for the cytokine IL-6 which we know can be released during an immune activation event and also know is strongly associated with causing autism. But, a study from the Middle East published roughly one year ago, provides a strong foundation for the IL-6-aluminum adjuvant connection. In this case, scientists were using aluminum to induce Alzheimer’s in rats, which they appear to have done successfully, showing that aluminum caused a 4-fold increase in IL-6:
If any of this remains confusing, I think VP’s description of aluminum adjuvant in the body will fill in any holes:
Quick Pause: The chicken-egg of immune activationI want to address a topic that triggered much of the exploration that drove me to write this article in the first place. Earlier this year, I got into a bit of a public squabble with Dr. Peter Hotez, a vaccine patent holder who also serves as a spokesperson for the vaccine industry. Dr. Hotez also has a daughter with autism, so this debate is very personal for him, as it is for me. Dr. Hotez is convinced that autism is “created” in utero as he explained to me, “my read of the scientific literature is that brains of children with autism, like ours, were that way by the first or second trimester of pregnancy.” Dr. Hotez bases his conclusion about autism’s timing on the work of a single study by Dr. Eric Courchesne and colleagues titled, “Patches of disorganization in the neocortex of children with autism.”which was published in 2014 in the New England Journal of Medicine. Dr. Hotez even took his refutation of some of the things I have publicly written about autism and vaccines a step further, and I think this is really the dividing line for many scientists, he wrote to me:
Does it? Does it defy reason that the re-wiring of the brain?—?that we now believe is caused by an immune activation event?—?could never happen after a child is born? This is the single most important question that needs to be answered to determine autism’s cause, and I think the answer will govern the autism causation debate from here on out:
I believe the science is very clear on this point. Read on. The evidence for post-natal autism triggers is strongRead study HERE The study that Dr. Hotez mentioned to me, the study that proved to him that autism was determined in utero, I have now read probably a dozen times. You can read it for yourself, it’s a study where scientists looked at the actual post-mortem brains of children with autism, and found striking differences in brain architecture. What the study didn’t do, because it would be impossible to do with post-mortem brains, some as old as 15 years, was speculate exactly WHEN the brain disorganization took place. And, really, how could they? I’m guessing Dr. Hotez was thrown off by the conclusion of this study, where the authors offered up a guess:
Did you catch what the study said, the part that Dr. Hotez turned into fact to support his claim (and by the way he has cited this study repeatedly in public writings about autism’s cause)? The authors said the disregulation they saw in the brains of children “probably” happened during “prenatal development stages.” I think the evidence you will see actually points to the opposite. VP explained it well:
VP went a little farther than Dr. Hotez did, providing this image which is hard to shake once you’ve seen it:  Click to enlarge What you can see fairly clearly is that the brain is far from done developing once a child is born. In fact, 5 separate phases of brain development are either in process or yet to start. Could an immune activation event after the child has been born impact brain development? Yes, it could. And, the published science also supports this view. In a study done in 2012, Wei and colleagues induced autism-like symptoms in mice by injecting them with IL-6 AFTER they were born. This is NOT a maternal immune activation event, this is an immune activation event of a newborn that leads to the development of symptoms of autism. Read study HERE The authors noted:
Still think Dr. Hotez has a point, that autism happens during gestation or never? Then this study will really blow your mind, from all the way back in 1981. Read study HERE In this case study of three children, published in Child Neurology, the authors describe three cases of sudden onset autism, all caused by infection and inflammation of the brain. It appears that not only can an infection trigger an immune activation event that leads to autism after a child is born, it can even happen to a child who is 5, 7, or 11 years old (the ages of the three children in this study). Are you reading this, Dr. Hotez?
Discovery #4: Hepatitis B vaccine induces IL-6 in postnatal ratsWhen this paper was published in China, no one I knew in the autism community mentioned it, I’m guessing because it was hard to patch together its significance. You had to appreciate all of Patterson’s work. You had to understand the IL-6 connection to autism. You had to appreciate the brand new insights about aluminum adjuvant toxicity, the low dose implications, and that aluminum adjuvant was ending up in the brain. And, you had to read a paper from China that covered a lot of other ground, as well as providing a missing link in the aluminum adjuvant-cytokine (IL-6)-autism hypothesis that it helped fortify. Read study HERE VP has written extensively about this study, I will start by quoting VP, but if you want a highly detailed scientific analysis of this study, check this out.
And, VP continues, explaining the timing of the injury to the Hep B rats:
This study is extraordinary. There were three different groups of rats: rats receiving the BCG vaccine (not given in the U.S.), rats receiving the Hepatitis B vaccine (given on day 1 of life in the U.S.) and a control group with no vaccine. The BCG vaccine does NOT contain aluminum adjuvant and the impact on the rat’s brains from BCG was actually positive! The Hep B vaccine rats, however, showed the kind of immune activation event we are seeing in autism (high IL-6) This is biological proof of the link between a vaccine?—?given to a post-natal animal?—?inducing an immune activation event, including the cytokine marker for autism, IL-6. A scientific first. Discovery #5: High levels of aluminum in autism brainsEarlier, I mentioned the December 2017 study published by Professor Chris Exley?—?“Aluminium in brain tissue and autism”?—?that found incredibly high levels of aluminum in the brain tissue of five people with autism. In an interview soon after his study was released, Dr. Exley explained:
Professor Exley and his colleagues were startled by something else: the location of the aluminum within the brains:
What Professor Exley found were macrophages, the kind the French scientists discovered were transporting aluminum into the brains of mice, loaded with aluminum, and serving as carriers to bring the aluminum into the brain. Dr. Exley’s study showed that the conclusion being drawn in the laboratory with mice were equally true in the brains of people with autism. It turns out the biological experiments using mice to gauge the impact of injected aluminum adjuvant were equally accurate when extrapolated to humans. In fact, Professor Exley was so shocked by the findings, it altered his view of the safety of using vaccines containing aluminum.
Dr. Exley just told parents not to get vaccines that constitute MOST of the childhood vaccine schedule. Dr. Exley, a tenured professor at Keele University of Bioinorganic chemistry and without peer the leading expert in the world on the neurotoxicity of aluminum. As an aside, and as to be expected, Dr. Exley’s study is already being subjected to withering criticism. As a parent really only interested in the TRUTH, I’m fine with this, it’s important that every meaningful criticism is considered and every conclusion criticized. I send Dr. Exley’s study to a former colleague of Dr. Paul Patterson. He’s not impressed, he writes, “I honestly don’t think it should have been published because it has a critical scientific flaw… The authors didn’t use any healthy control tissue, so we have no way of knowing what normal Al levels in a brain would by their method. Imagine, for example, if the blades they used to cut the brains had trace levels of Al that contaminated their tissue. If they had used healthy controls, you would have also seen high Al levels in the healthy brains as well. Since they had no such controls, their results are scientifically meaningless.” I share this response, in an email exchange, with Dr. Exley. I’ll provide his unedited response:
I ask him that it’s been like since the study was published, is it being considered by any “mainstream” scientists or organizations? What is the political fallout from your study like? Do you have a concern of being “Wakefielded” for your study? He responds:
A few weeks ago, Dr. Exley provided a very helpful interview about his new study, it’s short and worth watching: Five discoveries, a clear path to autismHere’s a simple graphic that I think spells out the process of triggering autism very clearly, as demonstrated by the published science I have just shared with you: (This graphic is from a great brochure created by Vaccine Papers, you can get a complete copy right HERE.) Published studies are showing that autism is caused by an immune activation event. The adjuvant in vaccines?—?aluminum adjuvant?—?can activate the brain’s immune system and is far more neurotoxic than previously realized?—?all the new science has been published in just the last few years. Aluminum can cause IL-6, the key cytokine implicated in autism. Chinese scientists?—?for the first time anywhere in the world?—?used a vaccine to trigger an immune activation event, and recorded elevated levels of IL-6 in rats. THIS is a biological basis for HOW a vaccine can cause autism. Remember what Dr. Hotez said to me? He said:
But, that’s exactly what the science is showing us. Vaccines, administered early and often, are igniting immune activation event after immune activation event. Here’s a different chart looking at the development of the brain over time, from a neuro-immunological perspective. Imagine 6–7 immune activation events (right after they receive 4–6 aluminum adjuvant containing vaccines in a single appointment) in certain vulnerable children during critical phases of brain development. With everything you’ve just read, is it really that hard to imagine?  Implications and questionsI can’t help but tie everything I read and see here to my own son’s experience. Born in 2002, my son seemed to get sicker with every vaccine appointment, and his head always seemed to be hurting. And, with each appointment, unusual behaviors and odd movements began to appear. A really sad reminder of this reality appeared in a study published just last week in Nature, that described how children with autism developed enlarged foreheads: Read study HERE “Brain enlargement has been observed in children with autism spectrum disorder (ASD), but the timing of this phenomenon, and the relationship between ASD and the appearance of behavioural symptoms, are unknown. Retrospective head circumference and longitudinal brain volume studies of two-year olds followed up at four years of age have provided evidence that increased brain volume may emerge early in development.” Wouldn’t the above theory about how autism is triggered do a pretty good job of explaining why these children have large (swollen) heads? As you know, the immune activation event leads to what Dr. Patterson called “an ongoing, permanent immune-system activation in the brains of autistic people.” And, guess what, permanent immune system activation means inflammation…which would lead to a “large brain” and a “swollen forehead.” Is that why children with autism are known to head bang? Perhaps you would too if you’re brain was in a state of permanent inflammation? Question: What about gastrointestinal disorders?So many children with autism experience gastrointestinal disorders, my son most certainly did. And, gastrointestinal distress is now fully appreciated to be a “co-morbid” condition of autism, according to Autism Speaks. But what, exactly, might cause it? You don’t have to look too far: Read study HERE
(Note: Down below I cite a second paper by Hsiao and colleagues that shows that an immune activation event can CAUSE gut dysbiosis, in the section titled “Heal the Microbiome.”) Question: What about all the other types of autoimmunity (food allergies, etc.) that are at epidemic levels, and often co-morbid with autism?Spearheaded by Israeli scientist Dr. Yehuda Shoenfeld, the scientific evidence that aluminum adjuvant is causing epidemics of a wide variety of auto-immune conditions is becoming overwhelming. Dr. Shoenfeld even has his own text book explaining this!  Click to order from Amazon “With the discovery of autoimmune/inflammatory syndrome induced by adjuvants (ASIA), the work of leading researchers from 14 countries on the role of adjuvants in different vaccines and how they can induce diverse autoimmune clinical manifestations in genetically prone individuals has been published in the newly released medical textbook, Vaccines and Autoimmunity.” Consider this article: “Researchers at the University of Virginia Health System’s Division of Asthma, Allergy & Immunology report that an era of food allergies that began with the post-millennial generation might be a response to vaccines containing the adjuvant alum, a known trigger for allergic traits. Alum is usually the name given to potassium aluminum sulfate when used in vaccines, the FDA states. Sometimes, aluminum hydroxide and even other forms of aluminum adjuvants are also referred to as alum in allergy research.” Dr. Shoenfeld’s groundbreaking study in 2013 explained the role of aluminum adjuvant in triggering autoimmunity across a wide variety of conditions: The study reads: “Notwithstanding that molecular mimicry and bystander activation in a genetically predisposed individual have been called to be responsible, the finger should be pointed at the adjuvants. One in particular has raised several distresses: aluminum. Indeed, this has been used as an adjuvant for the past 90 years but it is also an experimentally demonstrated neurotoxin. Experimental research has showed that alum adjuvants have a potential to induce serious immunological disorders in humans. Thus, efforts should be put in clarifying the potential threat of alum-containing vaccines.” Question: What about mercury?When my son was diagnosed with autism in 2004, the only thing parents were talking about was the mercury in vaccines. Thimerosal, a preservative made from ethyl-mercury, had recently been revealed to be in children’s vaccines far in excess of EPA safety guidelines. The autism rate was exploding, and a 2001 paper showed a compelling correlation between the symptoms of autism and the symptoms of mercury poisoning. 
The use of mercury in a vaccine seems insane to most rational people given the extreme neurotoxicity of mercury, which has been demonstrated in hundreds of published studies.We’ve learned that vaccine mercury travels straight to the brain of monkeys, that it depletes glutathione, a vital antioxidant, that it blocks critical pathways in methylation, and that mice injected with Thimerosal exhibit behaviors similar to autism. Thimerosal has been removed from most pediatric vaccines (beginning in 2002), but in an odd development, started being injected into pregnant women in 2004, when the flu shot (of which a portion contain thimerosal) was recommended for the first time by the CDC for pregnant women. So, does this article abandon the mercury-autism hypothesis? My personal answer is complex:
“How can 1 + 1 = 100? ‘Synergistic toxicity’ refers to the effect that when exposed to two toxins, the toxicity level is far greater than the additive toxicity levels of the two toxins.”
Question: What about the MMR, it has no aluminum adjuvant?The MMR vaccine does not contain aluminum adjuvant. Yet, many (but far from all) parents point to the appointment where their child received the MMR vaccine as a trigger for autism. We need more scientific data than we have about what exactly the MMR vaccine does to the brain (does it generate IL-6 or other cytokines?), but because we don’t know, we’re left to speculate. One obvious answer is that the MMR vaccine is the first live virus vaccine children receive (it’s typically given between age 12–18 months, most children have received 15–20 vaccines by then), and it’s a triple (measles, mumps, rubella) live virus. For an immune system bathed in aluminum adjuvant and possibly already simmering with activation events, this triple dose might push a child right over the edge. This might explain the seizures (an extreme immune activation event) that sometimes follow the MMR appointment. We also know that children who also receive the varicella vaccine (chicken pox) along with the MMR have higher rates of seizure events. This would make sense, four live viruses at once would likely challenge the immune system more than three, but we can’t explain exactly how the MMR biologically impacts the immune system the way we can for aluminum adjuvant, and now for Hepatitis B vaccine (thanks to Chinese scientists). Dr. Yehuda Shoenfeld discusses the fact that a live vaccine activates the immune system more than a vaccine using aluminum adjuvant:
But, a more obvious explanation has recently emerged. Namely, the MMR vaccines triggers something in the body known as MCP-1, which serves as a beacon to encourage aluminum-laden macrophages to rush to the brain. I’ll let VP explain:
Question: Didn’t they already prove vaccines don’t cause autism?If you’ve read this far, I assume you already know this is a fable. If you’re unsure, just look at this simple graphic. All those vaccine industry spokespeople who say “the science is settled” fail to mention that only one ingredient (thimerosal) and one vaccine (MMR) has ever been looked at for its relationship to autism. No vaccine containing aluminum adjuvant has ever been explored for its relationship to autism, despite a growing and clear body of evidence implicating aluminum adjuvant in causing “immune activation,” the central cause of autism. 
It’s also worth pointing out that in the early and mid-2000s when parents first started sounding the alarm about the connection between vaccines and autism, we had no biological evidence to support our view, we just had the collective experience of seeing our children disappear after vaccine appointments. Today, it’s a completely different world. Consider the words of Dr. Kimberley McAllister of the UC Davis Mind Institute just this past August (2016): “These MIA (maternal immune activation) animal models meet all of the criteria required for validity for a disease model: They mimic a known disease-related risk factor (construct validity), they exhibit a wide range of disease-related symptoms (face validity), and they can be used to predict the efficacy of treatments (predictive validity).” It’s time for the CDC, FDA, Autism Speaks, and the American Academy of Pediatrics to face the biological evidence staring us all in the face! Question: Aren’t you just “moving the goalposts” on the autism-vaccine hypothesis?Of course critics will say this. First it was the MMR. Then it was mercury. Then it was “too many, too soon.” What’s different now is very important: overwhelming published, peer-reviewed science making a clear connection between immune activation events, aluminum adjuvant, and autism. That’s why this article is filled with study references, not conjecture. What’s been true throughout the autism epidemic remains true today: an overwhelming (tens of thousands) number of parental reports of regression of their children into autism after vaccination. Implications for Treatment I want to know what, exactly, happened to my son. When he was diagnosed with autism in 2004, the prevailing understanding of autism in the parent community was that it was growing exponentially, many parents were seeing changes after vaccine appointments, and that mercury or a live virus (measles) were the most likely causes. We had no biological science. The understanding of aluminum or the aluminum adjuvant was comically simplistic, almost a throw away point. We had no idea what an immune activation event, a cytokine, or IL-6 meant. (In fact, if you want a good laugh, see how Dr. Paul Offit is still describing aluminum adjuvant, despite its now proven extreme neurotoxicity. He states: “Parents can be reassured that the trace quantities of aluminum in vaccines can’t possibly do harm.” Based on published science beginning in 2009, this is an unsupportable lie.) Everything you have read so far is based on published science. The grand theory of autism’s causation, in my opinion, holds together pretty strongly. Will we look back one day and say that aluminum adjuvant caused the autism epidemic the way we say that Thalidomide triggered birth defects? I think we will, but that’s just my opinion.What follows next is conjecture and opinion. I’m not a doctor, and this is most certainly NOT medical advice, but I do believe that the treatment of children suffering from autism may be radically altered by the simple description Dr. Patterson made of children with autism: “there’s an ongoing, permanent immune-system activation in the brains of autistic people.”If he’s right, and if aluminum adjuvant is the primary trigger of the immune activation, than the following ideas might prove helpful in reducing the symptoms of autism in children. (Please note that any links I include to actual products are just for illustrative purposes, I’m not endorsing anything and I have no commercial interests in any products or ideas mentioned here): 1. Get the aluminum adjuvant out of the body.I know that silica and zeolites are both considered possible ways to remove aluminum from the body. Will they also work on aluminum adjuvant? I have no idea. VP has a perspective on aluminum removal that cites a wide body of scientific research. Also, Dr. Exley is on the record advocating the consumption of silica-rich mineral water. Here’s an article about various waters: 2. Consider ketogenicsI was incredibly excited to see this study about the impact a ketogenic diet had on suppressing immune activation in mice. Could ketones play a role in reducing brain inflammation and turning off the brain’s immune system?  Read study HERE
It’s worth noting that the ketogenic diet has been used for years to help reduce seizures. Ketogenics are going through a bit of a revolution, with “exogenous ketones” now being made available as supplement products to put a body into ketosis more quickly. Could these exogenous ketones accelerate recovery? I have no idea, but this study alone seems to show its worth far more exploration. See another study from 2014: Potential Therapeutic Use of the Ketogenic Diet in Autism Spectrum Disorders. And, a study of the ketogenic diet with children with autism, way back in 2003. 3. Heal the microbiomeWe know that aluminum adjuvant can contribute to gastrointestinal distress. But, how do you heal that gut (the microbiome)? A 2013 study highlights the relationship between the gut microbiota, immune activation, and autism: Read study HERE Discussion:
There a wide variety of natural therapies to “heal the gut” that should be discussed with your health care professional. A more recent study: Emerging Roles for the Gut Microbiome in Autism Spectrum Disorder. 4. Vitamin DVP has an excellent section on the role Vitamin D can play in reducing immune activation, stating:
And, here’s a case report from China where a child’s autism symptoms improved dramatically from Vitamin D: Read study HERE 5. SeleniumSelective induction of IL-6 by aluminum-induced oxidative stress can be prevented by selenium Journal of Trace Elements in Medicine and Biology, 2012, Dale Viezeliene, Piet Beekhof, Eric Gremmer, Hiliaras Rodovicius, Ilona Sadauskien, Eugene Jansen, Leonid Ivanov This fascinating study from scientists in Lithuania and the Netherlands highlighted two things:
“Therefore it was concluded that short-term exposure to Al [aluminum] causes adverse effects on the intracellular oxidative stress processes in the liver, as reflected by the selective increase in the IL-6 concentration. This process can be restored by co-administration of the trace element Se [selenium] as a part of the glutathione redox system.” Next StepsI believe we may be far closer to a complete explanation of how autism?—?and many related autoimmune conditions?—?are being caused. Scientists from all over the world have created a compelling body of work to support an almost complete biological understanding of how autism is triggered by aluminum adjuvant inside the body, creating an immune activation event, and leading to autism?—?most of this research has been published in just the last 5 years. And none of it from Americans. Is everything published and written here true? Could the explanation really be that simple? Did a rising number of vaccines containing the aluminum adjuvant trigger an autoimmune epidemic, of which autism is the most severe, but not only, manifestation? Does an epidemic of food allergies, ADHD, learning disabilities, eczema, and diabetes fall into the same realm of causation?  Dr. Chris Shaw of. Canada Is is possible that injecting an immune system antagonist (aluminum adjuvant), all but guaranteed to cause immune activation events, has done just that in the brains of many of our children? Do even mildly impacted children also suffer from a permanent, simmering brain immune system activation? Should we believe the growing body of scientists from all over the world who are sounding the alarm about the impact injected aluminum adjuvant is having on our children?  Click to expand Is there any hope of recovery for all these impacted children? Will removing aluminum, introducing ketones to the brain, repairing the gut, and supplementing with Vitamin D do anything to alleviate autism and other ailments in children who have already been damaged? And, importantly, will these scientists who have published all this wonderful work pool their collective expertise and let the world know what they are learning? Will they take their exhortations for caution and further exploration?—?all buried inside their published studies?—?and publicly warn parents about what is becoming so clear? I’m heartened by a recent quote from Dr. Exley, someone clearly willing to exhibit moral courage:
In my opinion, we are much, much closer to understanding how autism has been triggered in so many children, and I hope this article is another step on the path to the truth. And, for so many of you out there doing everything you can to help you son or daughter with autism live the best possible life, perhaps a clearer understanding of how their autism was triggered will improve their chances for recovery. The three lettersIn the middle of 2017, three of the most important scientists in the field of aluminum adjuvant toxicity-Dr. Christopher Shaw of Canada, Dr. Chris Exley of England, and Dr. Romain Gherardi of France-took the extraordinary step of writing letters of caution to our American public health authorities. I provide their letters below. Dr. Christopher Shaw click to enlarge Dr. Romain Gherardi click to enlarge Dr. Chris Exley page 1, click to enlarge  page 2, click to enlarge About the author J.B. Handley is the proud father of a child with Autism. He and his wife co-founded Generation Rescue, a national autism charity, in 2005. He spent his career in the private equity industry and received his undergraduate degree with honors from Stanford University in 1991. He is also the author of “A lone FDA scientist could end the autism epidemic.” Learn more here.
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